The c‐myc proto‐oncogene is believed to be involved in the regulation of cell growth and differentiation. Deregulation of this gene, resulting in an inappropriate increase of gene product, can contribute to cancer formation. One of the ways in which the expression of the c‐myc gene can be deregulated is by the stabilization of the labile c‐myc mRNA. The rapid degradation of the c‐myc transcript appears to be mediated by at least two distinct regions in the mRNA. One lies in the (...) 3' untranslated region, and presumably consists of (A+U)‐rich sequences. The other lies in the C‐terminal part of the coding region and colocalizes with sequences encoding protein‐dimerization motifs. The exact mechanism by which the destabilizing elements function is not yet clear. Shortening of the poly(A) tail of the c‐myc message appears to precede degradation of the transcript. When translation is blocked, this shortening is slowed down and the mRNA is stabilized. This suggests that deadenylation is required before degradation of the mRNA body can take place. (shrink)

This paper argues that mental models of discourse are key in any theory of the interpretation of definite descriptions. It considers both referential and attributive uses of such descriptions, in the sense introduced by Donnellan.

This paper presents a new theory of modal reasoning, i.e. reasoning about what may or may not be the case, and what must or must not be the case. It postulates that individuals construct models of the premises in which they make explicit only what is true. A conclusion is possible if it holds in at least one model, whereas it is necessary if it holds in all the models. The theory makes three predictions, which are corroborated experimentally. First, conclusions (...) correspond to the true, but not the false, components of possibilities. Second, there is a key interaction: it is easier to infer that a situation is possible as opposed to impossible, whereas it is easier to infer that a situation is not necessary as opposed to necessary. Third, individuals make systematic errors of omission and of commission. We contrast the theory with theories based on formal rules. (shrink)

I contend that a great deal of western philosophical thought is based upon a mistaken assumption, and that is: there is something real that we can know. I argue that, on the contrary, insofar as our experience is of a world that has meaning, this experience is not of the world "as it really is," but of the world as we perceive it through language. The very process of making the world meaningful, or learning about it, is at the same (...) time a mediation of the world. ;Because the self has, for the most part, been conceived as some kind of object, in Part One I discuss the relationship between language and our experience of objects, and our experience of objects in time. In Part Two I examine the two traditional approaches to knowledge, and attempt to show that empiricism yields no knowledge of "reality" and that metaphysics is unmeaningful. I conclude that, while we cannot know what is real, we continue to desire to do so, and so continue to make the world meaningful in various ways. ;In Part Three I claim that the self is something that we cannot know--although we try to know ourselves by telling stories about ourselves to ourselves--and that all attempts to describe the self result in the creation of models. I define 'models' as broad, compelling representations of what the self is, but which are incapable of accommodating one or another obvious feature of human experience. ;In Part Four I apply all of the above to the disciplines of psychology and literary criticism. Specifically, I criticize Stanley Fish's notion of the interpretation of texts, and analyze what is called 'dissociative identity disorder' --a disorder that makes sense only on the assumption that many selves can inhabit a single body. ;Finally, in Part Five, I admit that this entire thesis is nonsense, insofar as it is an attempt to say: "This is how things are." I conclude, however, that there are greater and lesser pieces of nonsense in the world, and that the value of philosophy resides in being able to expose great nonsense as nonsense. (shrink)

This book is an exploration of human understanding, from the perspectives of psychology, philosophy, biology and theology. The six contributors are among the most internationally eminent in their fields. Though scholarly, the writing is non-technical. No background in psychology, philosophy or theology is presumed. No other interdisciplinary work has undertaken to explore the nature of human understanding. This book is unique, and highly significant for anyone interested in or concerned about the human condition.

This article outlines a theory of naive probability. According to the theory, individuals who are unfamiliar with the probability calculus can infer the probabilities of events in an extensional way: They construct mental models of what is true in the various possibilities. Each model represents an equiprobable alternative unless individuals have beliefs to the contrary, in which case some models will have higher probabilities than others. The probability of an event depends on the proportion of models in which it occurs. (...) The theory predicts several phenomena of reasoning about absolute probabilities, including typical biases. It correctly predicts certain cognitive illusions in inferences about relative probabilities. It accommodates reasoning based on numerical premises, and it explains how naive reasoners can infer posterior probabilities without relying on Bayes's theorem. Finally, it dispels some common misconceptions of probabilistic reasoning. (shrink)

John Laird was a Scottish philosopher who specialised in metaphysics and moral philosophy. In this early work, which was originally published in 1920, Laird set out to analyse some of the more perplexing problems of philosophical realism. The text includes a brief survey of philosophical realism at the beginning and critical notes throughout. This book will be of value to anyone with an interest in the works of Laird and the history of philosophy.

The authors outline a theory of conditionals of the form If A then C and If A then possibly C. The 2 sorts of conditional have separate core meanings that refer to sets of possibilities. Knowledge, pragmatics, and semantics can modulate these meanings. Modulation can add information about temporal and other relations between antecedent and consequent. It can also prevent the construction of possibilities to yield 10 distinct sets of possibilities to which conditionals can refer. The mental representation of a (...) conditional normally makes explicit only the possibilities in which its antecedent is true, yielding other possibilities implicitly. Reasoners tend to focus on the explicit possibilities. The theory predicts the major phenomena of understanding and reasoning with conditionals. (shrink)

Education is on the cusp of a configurational shift, or, as some may argue, in the midst of it. In the last twenty years the direct influence of corporations and their interest in leading educational agencies has substantially increased with no signs of stopping.1 The corporation has become a leader for systemic change in educational practice.2 This systematic change's emphasis on the mighty dollar brings about many different obstacles for educators and educational theorists to consider, one of these being the (...) way education's monetization affects both learners' and educators' motivation. Where does this shift to the focus of funds find such motivations? Looking through the lenses of both John Dewey and... (shrink)

This paper reviews current psychological theories of syllogistic inference and establishes that despite their various merits they all contain deficiencies as theories of performance. It presents the results of two experiments, one using syllogisms and the other using three-term series problems, designed to elucidate how the arrangement of terms within the premises affects performance. These data are used in the construction of a theory based on the hypothesis that reasoners construct mental models of the premises, formulate informative conclusions about the (...) relations in the model, and search for alternative models that are counterexamples to these conclusions. This theory, which has been implemented in several computer programs, predicts that two principal factors should affect performance: the figure of the premises, and the number of models that they call for. These predictions were confirmed by a third experiment. Dans cet article sont passées en revue les théories psychologiques du traitement des syllogismes. On établit qu'en dépit de leurs mérites variés toutes sont en défaut en tant que théories de la performance. On présente les résultats de deux expériences, une utilisant des syllogismes et l'autre des problémes avec des séries de trois termes conçues pour élucider comment l'arrangement des termes dans les premises affecte la performance. Ces données sont utilisées pour construire une théorie fondée sur l'hypothése que les gens construisent des modèles mentaux des premises, formulent des conclusions explicites sur les relations dans le modèle et cherchent des modèles qui seraient des contre-exemples pour leurs conclusions. Cette théorie, utilisée dans plusieurs programmes d'ordinateur, prédit que deux principaux facteurs affectent la performance: la figure des premises et le nombre de; modèles qu'ils mettent en jeu. Cette prédiction est confirmée dans les trois expériences. (shrink)

In A.J.P. XXXIII., pp. 426–435, Mr. A. C. Pearson attempted to prove that ὅТαѵ ‘not infrequently bears a causal signification … and that in such cases the temporal meaning is more or less evanescent, and sometimes entirely disappears.’ The use of ὅТαѵ where the verb refers to future time is not discussed, the purpose being ‘to establish that the classification which sums up the other occurrences of the construction as necessarily expressing “indefinite frequency” is incomplete; and that a rigorous insistence (...) on its universal applicability has vitiated the interpretation of numerous passages.’ In the question of ‘causal implication’ I am not particularly interested. It is useless to attempt to deny that our English since is a satisfactory translation of ὅТαѵ in many instances, though it is not, perhaps, an easy matter to state what is the exact force of since in such cases. As to ‘causal implication’ I shall merely point out that a cause, strictly speaking, precedes in time that of which it is the cause, whereas a ὅТε-clause properly defines a situation that is of the same time as the principal clause. The question I wish to raise is whether the implication of ‘indefinite frequency’ has disappeared so completely in certain passages as Mr. Pearson thinks it has. Some of his examples are very interesting. It is not easy to see repeated action in them, and we may admit that critics have not ‘seriously pondered the results which flow from their adherence to established convention.’ But has Mr. Pearson seriously pondered the results which flow from his own conclusions?' So far as I can see, he makes no distinction at all between cases of ὅТαѵ with the subjunctive, ‘where no other relation than that of causality appears to exist between the subordinate and principal clauses’ and cases of ‘causal’ ὅТε with the indicative. (shrink)

Good reasoning can lead to success; bad reasoning can lead to catastrophe. Yet it's not obvious how we reason, and why we make mistakes. This book by one of the pioneers of the field, Philip Johnson-Laird, looks at the mental processes that underlie our reasoning. It provides the most accessible account yet of the science of reasoning.

This paper reviews the location of Responsible Research and Innovation approaches within the access and benefit sharing policy spaces of the Convention on Biological Diversity and Nagoya Protocol. We describe how a range of dialogues on ethical research practices found a home, almost inadvertently, within the ABS policy process. However, more recent RRI dialogues around emerging technologies have not been similarly absorbed into ABS policy, due in part to the original framing of ABS and associated definitional and scope issues. Consideration (...) is given to the challenges posed to these policy processes by the transformative and rapid nature of scientific and technological change today, including the emerging field of synthetic biology. Drawing on experiences from regulating ABS, we emphasize that the integration of RRI into policies for new, emerging, or poorly understood activities such as synthetic biology faces deficiencies such as limits to government capacity, jurisdictional confusion, shortages in funds, and an absence of strategic approaches. We conclude that a coordinated combination of diverse policy processes within the CBD might provide an invaluable space for RRI dialogues on social justice, sustainability, biosafety, and other issues raised by emerging technologies. (shrink)

We describe a fully abstract semantics for a simple functional language with locally declared names which may be used as pointers to names. It is based on a category of dialogue games acted upon by the group of natural number automorphisms. This allows a formal, semantic characterization of the key properties of names such as freshness and locality.We describe a model of the call-by-value λ-calculus based on these games, and show that it can be used to interpret the nu-calculus of (...) Pitts and Stark. We then construct a model of our pointer-language by extending our category of games with an explicit representation of the store, using a notion of semantic garbage-collection to erase inaccessible pointers. Using factorization and decomposition techniques, we show that the compact elements of our model are definable as terms, and hence it is fully abstract. (shrink)